GENIUS-CHD is an international consortium of studies of patients with coronary heart disease (either stable disease or acute coronary syndromes) who have had blood or tissue samples stored for analysis and have then been prospectively followed for subsequent events such as death or myocardial infarction.
Many of these studies have been created by investigators seeking to identify bio-markers of risk or genetic variations that lead to these groups of patients succumbing to these adverse events. Others are trials or studies created for other purposes but with stored samples and prospective follow up
Individually many studies are relatively small and although they can yield some insights, they often fail to show effects due to a lack of statistical power. Importantly negative findings are hard to interpret. Collectively, however, these studies are powerful enough to answer many important questions and offer opportunities to replicate or validate novel findings.
To date over 63 cohorts participate in the consortium, from 17 countries, including over 270,000 patients, making this the largest effort of its kind in studying determinants of risk for subsequent CHD events